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Adolescent mental health continues to be a pressing public health concern across the globe, in spite of renewed efforts in recent years to improve mental health and wellbeing outcomes. With many mental health ...
Social prescribing links people to activities and services typically provided by local voluntary and community sectors to address social determinants of health and wellbeing. People living with long-term healt...
Daratumumab (Dara)-based regimens have been investigated in randomized controlled trials (RCTs) involving patients with newly diagnosed and previously untreated multiple myeloma (NDMM), but the optimal daratum...
Research teams report challenges in conducting overviews and many of these relate to the synthesis of outcome data from multiple reviews that lead to unclear evidence. This limits research from being used by p...
This study aimed to evaluate the prevalence of B-complex vitamin deficiencies in Brazilian women of childbearing age, pregnant women, and lactating women.
Adherence to statin therapy is crucial for reducing the recurrence of cardiovascular events. Numerous methods exist to measure medication adherence, including those based on prescription data, patient self-rep...
Advancements in novel peptides significantly affect cancer diagnosis by targeting cancer-specific markers, thereby improving imaging modalities, such as positron emission tomography combined with computed tomo...
Stroke recovery is a critical global-health priority; there is growing interest alternative therapies in scalp acupuncture (SA) to overcome the limitations of conventional treatments and improve outcomes. This...
This study comprehensively analyzes the diagnostic criteria, eradication indications, treatment, and other information in the latest guidelines published by various countries around the world, so that research...
Myasthenia gravis (MG) is a chronic autoimmune disorder affecting the neuromuscular junction. The emergence of molecular therapies, such as monoclonal antibodies, B-cell-depleting agents, and chimeric antigen ...
Vaccination is a crucial public health intervention that has significantly reduced the incidence of infectious diseases. Vaccine-related interventions refer to strategies implemented to enhance vaccination upt...
Although the systemic inflammation response index (SIRI) is often associated with prognostic significance in esophageal cancer (EC) patients, the results continue to be conflicting. We focused on identifying S...
Prior systematic reviews highlight that accessing specialist healthcare to treat chronic conditions can be obstructed by variations in referral rates, inappropriate referrals, and poor communication. Structure...
Loneliness can pose serious health and psychological concerns among community-dwelling older adults. Meaning-centred interventions, which aim to help individuals find meaning in their lives, appeared to allevi...
Cancer’s rising incidence and growing survivor population underscore the need for strategies to enhance health and quality of life. Outdoor physical activity (PA) settings may provide unique benefits, yet evid...
Long-acting reversible contraceptives (LARCs), including implants and intrauterine contraceptive devices (IUCDs), are essential in preventing unintended pregnancies and empowering women by providing long-term,...
In recent years, endocan has emerged as a potential biomarker in various medical conditions. This multifaceted molecule, involved in key processes such as inflammation and endothelial dysfunction, has shown pr...
Spinal manipulative therapy (SMT) is frequently used to manage neck pain; however, its efficacy and safety in treating acute neck pain (ANP) remain uncertain and require further investigation.
Loneliness is more pronounced in individuals with diabetes; however, limited studies have investigated loneliness and its risk factors. This study estimated the pooled prevalence of loneliness and identified i...
This review aims to systematically evaluate the application of Jueyin disease theory in the diagnosis and treatment of gangrene within the framework of traditional Chinese medicine (TCM). Through systematic re...
Clinical research is essential for evidence-based decision-making in healthcare practice, but its conduct is hindered by various barriers. While previous studies suggest that clinical research units (CRUs) pro...
The number of re-biopsied blastocysts is widely increasing in IVF cycles and concerns regarding retesting, which involves double biopsy and vitrification-warming, have been raised. The re-biopsy intervention s...
The rise of powerful search engines (e.g., Google) make the searching for gray literature more feasible within the time and resources of a typical systematic review. However, there are no hypothesis-testing st...
More than one-third of the population in developed countries is aged 50 and older (hereafter older adults), and this proportion has been increasing every year. Aging is associated with labor shortages which pl...
Tobacco use is a global issue, and non-combustible nicotine products (NCNPs) like electronic nicotine delivery systems, nicotine pouches, snus, and nicotine replacement therapies offer potential risk/harm redu...
Informal caregiving roles are predominantly assumed by women, who often experience unique challenges related to physical, emotional, and social stress due to entrenched gender disparities. Within this context,...
Maternal mortality is a critical public health issue, especially in low- and middle-income countries (LMICs). Maternal healthcare services (MHS), including antenatal care (ANC) visits, skilled birth attendants...
To systematically evaluate the effect of acupuncture combined with Western medicine on vertebrobasilar artery hemodynamics and its clinical efficacy in patients with cervical vertigo. To provide a reliable evi...
Traditionally, family members take care of older relatives in South Asian societies, and there is a strong reciprocal filial obligation through intergenerational family relations. The changing family structure...
Our previous guide to estimating hazard ratios (HRs) from published summary (aggregate) data has become very widely used, but many still have difficulties knowing when and how to apply the methods. Informed by...
There are indications that clinical studies investigating the surgical treatment of acetabular fractures assess different outcomes. This heterogeneity reduces the comparability of study results and, thus, limi...
In China, sodium cantharidinate/vitamin B6 (SC/VB6) injection has been approved since 2002 for the treatment of lung cancer and primary liver cancer. In addition to these authorized indications, clinical appli...
Two genes are synthetically lethal if loss of function of either one of the two genes does not result in cell death, whereas loss of function of both genes together results in being detrimental to cell surviva...
This study aimed to systematically evaluate the efficacy of electroacupuncture and manual acupuncture for treating vascular dementia and to determine the optimal acupuncture point combination scheme for efficacy.
Stakeholder involvement in evidence syntheses has the potential to enhance the quality and relevance of reviews. However, adolescents rarely participate in evidence synthesis, mainly because their role and inf...
Chronic inflammation is a critical public health concern that, in children and adolescents, increases the long-term risk of a variety of different health issues. While mind–body therapies like yoga, meditation...
Sarcopenic obesity (SO) in older adults is associated with certain adverse outcomes, including falls, fractures, and disability, all of which affect patient quality of life, represent an economic burden, and p...
Children exposed to severe malaria may recover with gross neurologic deficits (GND). Several risk factors for GND after cerebral malaria (CM), the deadliest form of severe malaria, have been identified in chil...
Prior studies have 3suggested that theta burst stimulation (TBS) may be a promising intervention for the rehabilitation of aphasia after stroke. However, the results of these investigations have been inconsist...
While growing evidence highlights the harmful effects of waterpipe smoking (WPS), detailed information about its association to chronic diseases remains limited. This systematic review and meta-analysis explor...
Tobacco consumption continues to pose a substantial global public health threat, resulting in more than 8 million preventable deaths annually. The WHO Framework Convention on Tobacco Control (FCTC) negotiated ...
This review aimed to evaluate the therapeutic effects of Reiki therapy on quality of life.
The assessment and enhancement of lower limb motor function in hemiplegic patients is of paramount importance. The emergence of lower limb rehabilitation robots offers a promising avenue for improving motor fu...
Allergic Rhinitis (AR) is a prevalent chronic respiratory condition with limited long-term relief from Western medications. Interest in Traditional Chinese Patent Medicines (TCPMs) as a complementary approach ...
Perioperative neurocognitive disorders (POND) are common in older adults and are associated with adverse outcomes. This meta-analysis aimed to evaluate the efficacy and safety of esketamine for the prophylaxis...
To consolidate current evidence on predictors of neurological outcome following extracorporeal cardiopulmonary resuscitation (eCPR) in patients with cardiac arrest.
Clinical practice guidelines (CPGs) often fail to be fully implemented in practice. One barrier to CPG implementation is inconsistency between recommendations and existing practice patterns. This can include p...
Citation Impact 2023
Journal Impact Factor: 6.3
5-year Journal Impact Factor: 4.5
Source Normalized Impact per Paper (SNIP): 1.919
SCImago Journal Rank (SJR): 1.620
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Systematic Reviews