Table 7 Symptoms indicative of autonomic nervous dysfunction
Literature | Intervention measures | Experimental group | Control group |
|---|---|---|---|
Chong Yan (2022) [12] | Batoclimab 340 mg/ batoclimab 680 mg | Five cases of hyponatremia, two cases of hypomagnesemia, one case of hypoproteinemia, two cases of hyperuricemia, one case of hypokalemia, three cases of dropsy, seven cases of injection site reactions, one case of nausea, one case of toothache, two cases of diarrhea, one case of sore gums, one case of abdominal pain, two cases of muscle twitching, one case of diseases of the skin and subcutaneous tissues, one case of pruritus, one case of rash, one case of sweating at night, one case of cough, one case of sleep disturbances, one case of anxiety, four cases of dizziness, one case of headache, one case of palpitations, one case of blurred vision, one case of frequent urination | Four cases of hyponatremia, three cases of hypomagnesemia, one case of hypokalemia, two cases of injection site reactions, two cases of hypercholesterolemia, four cases of urinary tract infection, one case of upper respiratory tract infections, one case of herpes simplex, one case of folliculitis, one case of blepharitis, one case of weight gain, one case of decreased albumin, one case of increased blood cholesterol, four cases of dizziness, one case of headache |
James F. Howard Jr. (2019) [14] | Efgartigimod | Four cases of headache, one case of nausea, one case of diarrhea, one case of abdominal pain, four cases of decreased lymphocyte count, two cases of decreased monocyte count, two cases of increased neutrophil count, two cases of muscle pain, one case of pruritus, one case of runny nose | Three cases of headache, one case of nausea, one case of diarrhea, one case of abdominal pain, two cases of arthralgia, two cases of pruritus, one case of runny nose, two cases of tooth abscess, two cases of toothache |
James F. Howard Jr. (2021) [15] | Efgartigimod | Thirty-nine cases of infection, three cases of infusion-related reaction events, twenty-four cases of headache, ten cases of nasopharyngitis, seven cases of nausea, six cases of diarrhea | Thirty-one cases of infection, eight cases of infusion-related reaction events, twenty-three cases of headache, fifteen cases of nasopharyngitis, nine cases of nausea, nine cases of diarrhea |
Vera Bri (2021) [16] | Rozanolixizumab | Twelve cases of headache, one case of fatigue, one case of nasopharyngitis, one case of upper respiratory tract infections, one case of muscle twitching, two cases of muscle weakness, one case of dizziness | Two cases of headache, two cases of diarrhea, three cases of fatigue,3 three cases of nasopharyngitis, one case of upper respiratory tract infections, one case of muscle twitching, three cases of dizziness, one case of nausea, one case of vomiting, one case of dyspnea |
James F. Howard Jr. (2017) [17] | Eculizumab | Six cases of myasthenia gravis worsens, ten cases of headache, ten cases of upper respiratory tract infections, nine cases of nasopharyngitis, eight cases of nausea, eight cases of diarrhea, six cases of muscle weakness | Fifteen cases of myasthenia gravis worsens, two cases, twelve cases of headache, twelve cases of upper respiratory tract infections, ten cases of nasopharyngitis, nine cases of nausea, eight cases of diarrhea, eleven cases of muscle weakness |
James F. Howard Jr. (2020) [18] | Zilucoplan 0.1 mg/kg Zilucoplan 0.3 mg/kg | Two cases of nausea, five cases of injection site reactions, one case of bruising, six cases of headache | One case of injection site reactions, one case of headache |
Tuan Vu (2022) [19] | Ravulizumab | Sixteen cases of headache, thirteen cases of diarrhea, nine cases of nausea, one case of myasthenic gravis crisis, two cases of death, one case of difficulty swallowing, one case of tendonitis | Twenty-three cases of headache, eleven cases of diarrhea, nine cases of nausea, two cases of cellulitis, one case of herpes zoster, one case of injection site reactions |
Karen Hewett (2018) [20] | Belimumab 10 mg/kg | Three cases of influenza, three cases of nausea, four cases of diarrhea, three cases of headache, three cases of back pain | Six cases of hormonal obesity, ten cases of gastrointestinal reactions. The exact number of other adverse events is not listed |
Fredrik Piehl (2022) [21] | Rituximab 500 mg | Seven cases of upper respiratory tract infections, eight cases of musculoskeletal pain, six cases of diarrhea, four cases of nausea, three cases of rash | Eight cases of upper respiratory tract infections, five cases of musculoskeletal pain, two cases of diarrhea, one case of nausea |
Richard J. Nowak (2022) [22] | Rituximab | Six cases of arthralgia, eleven cases of headache, twelve cases of upper respiratory tract infections, three cases of fatigue, two cases of back pain, three cases of nausea, four cases of muscle weakness | Thirteen cases of headache, five cases of upper respiratory tract infections, nine cases of fatigue, eleven cases of back pain, ten cases of nausea, four cases of muscle weakness, seven cases of paresthesia |