Synthetic lethality in cancer: a protocol for scoping review of gene interactions from synthetic lethal screens and functional studies

Table 1 Synthetic lethal gene pairs and associated cancers identified from genetic screens and functional studies

S. No.	Gene	Synthetic lethal partner	Cancer type
1	ARID1A	TEAD1	Hepatocellular carcinoma [32]
2	TSC2	STK11	Non-small cell lung cancer [17]
3	KDM5C	BAP1	Diverse cancers [17]
4	SMARCA4	ARID1A	Diverse cancers such as ovarian cancer, breast cancer, lung adenocarcinoma, clear cell renal cell carcinoma [17]
5	SMARCA4	PTEN	Cowden syndrome, hamartomas, and other diverse cancers [17]
6	ARID1A	ARID1B	Neuroblastoma and other diverse cancers [17]
7	ARID1A	EZH2	Breast cancer, prostate cancer, and other diverse cancers [17]
8	PTEN	CHD1	Cowden syndrome, hamartomas and other diverse cancers [17]
9	WEE1	ATR	Breast cancer [28, 30]
10	BRG1	PTEN	Prostate cancer [33]
11	WRN	MMR genes	Colon cancer [34]
12	TP53	MDM2	TP53 is a critical tumor suppressor gene that is mutated in more than half of the human cancers [25]
13	TP53	MYC	TP53 is a critical tumor suppressor gene that is mutated in more than half of the human cancers [31]
14	CCNE1	PKMYT1	High-grade serous ovarian cancer, uterine tumors, and gastro-oesophageal cancers [35]
15	BRCA1/2	CIP2A	BRCA1/2 mutated cancers such as breast and ovarian cancer [26]
16	BRCA2	APEX2 and FEN1	BRCA2 mutated cancers such as breast and ovarian cancer [36]
17	SF3B1	BRCA1/2	BRCA2 mutated cancers such as breast and ovarian cancer [28]
18	KRAS	NOP56	Lung cancer [29]

ISSN: 2046-4053