Table 1 Overview of demographics
Study | Year | Geographical origin | Number of HSV-positive patients reported | Age (years) | Sex female (%) | HSV type | Diagnostic proof | Immunosuppression (%) |
|---|---|---|---|---|---|---|---|---|
Retrospective/multicenter | ||||||||
 Cag et al. [2] | 2016 | Europe/Middle East/North Africa | 496 | Median 50.5, IQR 33.3–63 | 53.6 | 351 HSV-1, 83 HSV-2, 62 not specified | PCR | NR |
 De Montmollin et al. [19] | 2022 | Europe | 273 | Median 64.6, IQR 55.5–73.7 | 49.8 | NR | PCR | 12.1 |
 Poissy et al. [20] | 2009 | Europe | 184 | Median 58 | 44.6 | NR | PCR | NR |
 Kaewpoowat et al. [16] | 2016 | North America | 80 | Median 40.5, range 18–82 | 62.5 | NR | PCR | 6.3 |
 Chow et al. [19] | 2015 | North America | 60 | Mean 56.8, SD 19.2 | 50 | 57 HSV-1, 3 HSV-2 | PCR | 0 |
 Omland et al. [22] | 2008 | Europe | 49 | Median 39, IQR 33–45 | 77.6 | 0 HSV-1, 49 HSV-2 | PCR | 6.1 |
 Gennai et al. [6] | 2016 | Europe | 36 | Median 60, IQR 55–73 | 61.1 | NR | PCR | NR |
 Afonso et al. [23] | 2007 | North America | 20 | Median about 40 | majority female | 1 HSV-1, 19 HSV-2 | PCR | NR |
Retrospective/monocenter | ||||||||
 Moon et al. [3] | 2014 | Korea | 95 | Median 34, range 16–85 | 54.7 | 21 HSV-1, 74 HSV-2 | PCR | 6.3 |
 Mulatero et al. [24] | 2022 | France | 76 | Mean 55, range 16–92 | 51.3 | 72 HSV-1, 4 HSV-2 | PCR | 10.5 |
 Singh et al. [8] | 2016 | North America | 45 | Median 66, IQR 53.5–78 | 71.1 | 33 HSV-1, 9 HSV-2, 3 not specified | PCR | 22.2 |
 Tan et al. [26] | 2012 | North America | 29 | Mean 55.1, SD 16.1, range 26–79 | 51.7 | NR | PCR | 48.3 |
 Miller et al. [25] | 2013 | North America | 28 | Mean 38, SD 19–55 | 78.8 | 0 HSV-1, 29 HSV-2 | PCR | 0 |
 Babaei et al. [27] | 2021 | Middle East | 21 | Mean 62.2 | 42.8 | NR | PCR | NR |
 Esiri et al. [21] | 1982 | Europe | 21 | Mean 45.9, range 18–81 | 61.9 | 21 HSV-1, 0 HSV-2 | brain biopsy or autopsy | NR |
 Bewersdorf et al. [14] | 2019 | Europe | 18 | Median 54.7, range 20–90 | 50 | NR | PCR | 27.8 |
 Studahl et al. [15] | 2009 | Europe | 17 | Mean 57.8, range 32–90 | 41.2 | NR | PCR | NR |
 Basaran et al. [16] | 2019 | Europe | 16 | Mean 53.37, SD 16.59 | 62.5 | 16 HSV-1, 0 HSV-2 | PCR | NR |
 Alessandro et al. [17] | 2018 | South America | 16 | Median 38, range 22–84 | 31.1 | 9 HSV-1, 5 HSV-2, 1 both, 1 not specified | PCR | 0 |
 Momméja-Marin et al. [18] | 2003 | Europe | 13 | Median 37, range 29–77 | 38.5 | 7 HSV-2, 6 not specified | PCR | 100 |
 Oyanguren et al. [10] | 2013 | Europe | 12 | Mean 67.8 | 58.3 | 12 HSV-1, 0 HSV-2 | PCR | NR |