Table 2 Methodological assessment of included studies
From: HEMA-free versus HEMA-containing adhesive systems: a systematic review
Study ID | Study design | Population | Intervention group | Control group | Outcome | Recall period | Recall rate | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of patients and gender | No. of restorations and type of cavity | Mean range of patients | HEMA-free | Success rate or AFR | HEMA-containing | Success rate or AFR | Evaluation criteria | Evaluation parameters | ||||
(1) Moretto et al. [19] 2013 | RCT Parallel | Total = 30 Male = 12 Female = 18 | 175 NCCLs | 20–69 years | G-Bond (GC, Tokyo, Japan) | 97.6% | Clearfil 3S Bond (Kuraray, Tokyo, Japan) | 92.6% | Vanherle criteria [24] | Retention, marginal adaptation Marginal discoloration, secondary caries, post- operative sensitivity tooth vitality | 3 years | 96.7% |
(2) Van Dijken [23] 2013 | RCT Split mouth | Total = 54 Male = 30 Female = 24 | 115 Class II | 24–77 years Mean = 57.1 | G-Bond (GC Corp, Tokyo, Japan) | 91.5% | FL Bond 2-step SEA (Shofu, Kyoto, Japan) | 82.3% | Modified USPHS | Anatomical form, marginal adaptation, marginal discoloration, color match surface roughness, caries, post- operative sensitivity | 6 years | 96.5% |
(3) Van Dijken [8] 2013 | RCT Split mouth | Total = 67 Male = 34 Female = 33 | 169 NCCLs | 39–84) years Mean = 64.7 | A single-step HEMA-free G-Bond (GC Corp, Tokyo, Japan) | nr AFR = 1.6% | (XP Bond, Dentsply/ DeTrey, Konstanz, Germany | nr AFR = 5.4% | Modified USPHS | Retention, marginal adaptation, marginal discoloration, secondary caries, post- operative sensitivity , color change, surface | 5 years | 94% |
−3-step HEMA/TEGDMA free etch-and-rinse (cfm, Saremco AG, Rebstein, Switzerland) | nr AFR = 1.7% | |||||||||||
(4) Van Landuyt et al. [9] 2014 | RCT Parallel | Total = 52 Male = nr Female = nr | 267 NCCLs | nr | G-Bond (GC, Tokyo, Japan) | 87.4% | Optibond FL (Kerr, Orange, CA, USA) | 90.9% | Vanherle criteria | retention, marginal integrity, marginal discoloration, caries occurrence, sensitivity | 5 years | 86.5% |
(5) Peumans et al. [20] 2018 | RCT Parallel | Total = 52 Male = nr Female = nr | 267 NCCLs | nr | 1SEa G- Bond (GB; GC, Tokyo, Japan) | 80.3% | 3E&Ra Optibond FL (OFL; Kerr, Orange, CA, USA) | 79.5% | Vanherle criteria | Retention Marginal integrity Marginal discoloration Caries post-operative sensitivity | 9 years | 82.6% |
(6) Tekce et al. [21] 2018 | RCT Split mouth | Total = 40 Male = 15 Female = 25 | 160 Class I | 18–55 years Mean = 23.3 | G-aenial Bond (GC Corp, Tokyo, Japan) | 100% | Clearfil S3 Bond (Kuraray Medical Inc, Tokyo, Japan) | 100% | Modified USPHS | Retention, marginal adaptation, marginal discoloration, secondary caries, color match, loss of anatomic form, surface | 2 years | 87.5% |
(7) Oliveira et al. [22] 2023 | RCT parallel | Total = 17 Male = 8 Female = 9 | 60 NCCLs | 23–39 years Mean = 30 | Prime & Bond U (Dentsply Sirona, Konstanz,Germany) | nr | -Optibond All-in-One( Kerr, New South Wales, Australia) | nr | Modified USPHS | Retention, marginal adaptation Marginal staining, post- operative sensitivity Secondary caries | 2 years | 96.6% |
-Clearfil SE (Kuraray Medical Inc., Tokyo, Japan) | ||||||||||||