Systematic review of the application of the Kidney Failure Risk Equation and Oxford classification in estimating prognosis in IgA Nephropathy

Table 1 Parameters required for each prognostic algorithm

Variable	KFRE	OC	IRP
Sex	✔
Age	✔		✔
Race			✔
Location	✔
eGFR	✔		✔
Proteinuria^a	✔		✔
MAP			✔
M^b		✔	✔
E^b		✔	✔
S^b		✔	✔
T^b		✔	✔
C^b		✔
RASB use at time of biopsy			✔
Immunosuppression use at/prior to biopsy			✔
Outcome	Risk of kidney failure at 2 and 5 years		Risk of composite outcome of 50% decline in eGFR and kidney failure at 5 years

KFRE kidney failure risk equation, OC Oxford classification, IRP IgAN Risk Prediction tool, eGFR estimated glomerular filtration rate (ml/min/1.73 m²), MAP mean arterial pressure (mmHg), M mesangial hypercellularity score, E endocapillary hypercellularity score, S segmental sclerosis score, T tubular atrophy/interstitial fibrosis score, C crescents score, RASB renin-angiotensin system blockers
^aProteinuria expressed as urinary albumin-creatinine ratio in KFRE and g/day in IRP
^bObtained by renal biopsy

ISSN: 2046-4053