Table 2 Meta-regression analysis for different parameters
Parameter | Sensitivity (95% CI) | Specificity (95% CI) | |
|---|---|---|---|
Type of research | Prospective (4 studies) | 69% (48–90%) | 99% (97–100%) |
Retrospective (9 studies) | 80% (69–90%) | 98% (94–100%) | |
Meta-regression P-value | 0.13 | 0.00 | |
Sequencing conditions | BGISEQ (7 studies) | 72% (57–86%) | 98% (93–100%) |
Others (6 studies) | 82% (70–94%) | 99% (97–100%) | |
Meta-regression P-value | 0.07 | 0.27 | |
Homogenization | Yes (7 studies) | 67% (53–80%) | 99% (95–100%) |
No (6 studies) | 86% (77–94%) | 99% (95–100%) | |
Meta-regression P-value | 0.00 | 0.07 | |
Sample pre-treatment | With bead-beating (6 studies) | 82% (77–94%) | 99% (97–100%) |
Without bead-beating (7 studies) | 72% (57–86%) | 98% (93–100%) | |
Meta-regression P-value | 0.87 | 0.02 | |