The best ovarian reserve marker to predict ovarian response following controlled ovarian hyperstimulation: a systematic review and meta-analysis

Table 5 Subgroup meta-analysis results based on sample size

	Median sample size ^*	Number of studies		Number of participants		Ln DOR (95%CI)		SE		P-value^**		I²(%)	T	T² (SE)	Cochran's Q (P-value)
	Median sample size ^*	Large	Small	Large	Small	Large	Small	Large	Small	Large	Small	I²(%)	T	T² (SE)	Cochran's Q (P-value)
*Poor response*
AMH	219	8	14	16873	1872	2.58 (1.84, 3.31)	0.43 (-1.50, 0.63)	0.37	0.54	< 0.0001	0.424	93.44	1.13	1.29 (0.49)	174.08 (< 0.0001)
AFC	200	6	10	13656	1409	3.22 (2.19, 4.25)	-1.14 (-2.63, 0.34)	0.52	0.76	< 0.0001	0.13	95.15	1.43	2.06 (0.87)	175.07 (< 0.0001
FSH	162.5	4	6	3404	675	1.21 (0.55, 1.87)	-0.19 (-1.22, 0.83)	0.33	0.52	0.0003	0.7	77.91	0.64	0.41 (0.32)	31.33 (0.0001)
E2		2	2	333	162	0.01 (-0.86, 0.88)	1.46 (0.15, 2.78)	0.44	0.66	0.98	0.02	17.12	0.32	0.10 (0.62)	2.13 (0.34)
*High response*
AMH	241	7	7	8219	983	2.33 (1.70, 2.96)	-0.37 (-0.61, 1.35)	0.32	0.50	< 0.0001	0.45	91.11	0.79	0.63 (0.33)	65.20 (<0 .0001)
AFC	219	4	4	3552	665	3.26 (1.34, 5.17)	-0.86 (-3.43, 1.69)	0.97	0.30	0.0008	0.50	92.97	0.62	2.65 (1.86)	40.85 (< 0.0001)
FSH	188	2	5	3060	666	1.01 (-0.17, 2.21)	-0.29 (-1.34, 1.93)	0.60	0.83	0.09	0.72	87.55	1.00	01.01 (0.77)	23.26 (0.0003)
E2	123	1	2	227	213	0.12 (-0.55, 0.81)	0.52 (-0.42, 1.47)	0.34	0.48	0.71	2.27	0.00	0.00	0 (0.34)	0.14 (0.70)

Abbreviations: AFC Antral follicular count, AMH Anti, Mullerian hormone, CI Confidence interval, DOR Diagnostic odds ratio, AUC Area under curve, E2 Estradiol, FSH Follicle stimulating hormone, Ln Logarithm, MSS Median sample size, ORM Ovarian reserve marker, pAUC Partial AUC, SE standard error, T Tau, T² Tau squared. Large and small represent sample size
^*Studies classified as ‘small sample size’ include those with fewer participants than the median sample size, while ‘large sample size’ refers to studies with more participants than the median”
^**P-value for Ln DOR

ISSN: 2046-4053