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Table 4 Subgroup meta-analysis results based on study design

From: The best ovarian reserve marker to predict ovarian response following controlled ovarian hyperstimulation: a systematic review and meta-analysis

 

Number of studies

Number of participants

Ln DOR (95%CI)

SE

P-value*

I2(%)

T

T2 (SE)

Cochran's Q (P-value)

Poor response

 Cohort

  AMH

15

17772

2.60 (2.01, 3.20)

0.30

< 0.0001

93.86

1.07

1.14 (0.51)

128.55 (< 0.0001)

  AFC

10

14240

2.61 (1.86, 3.35)

0.37

< 0.0001

74.65

0.75

0.57 (0.53)

18.05 (0.00)

  FSH

5

3315

1.40 (0.52, 2.28)

0.44

<0.0001

77.22

0.82

0.68 (0.70)

13.95 (0.00)

  E2

2

290

0.56 (-1.57, 2.70)

1.09

0.60

72.67

1.34

1.81 (3.52)

3.65 (0.05)

Cross Sectional

  AMH

5

723

1.99 (0.88, 3.10)

0.56

0.0004

86.20

1.15

1.33 (1.13)

35.06 (< 0.0001)

  AFC

4

584

1.01 (0.59, 1.44)

0.21

<0.0001

0.00

0

0 (0.14)

0.01 (0.99)

  FSH

4

679

0.71 (0.34, 1.08)

0.19

0.0002

0.00

0

0 (0.11)

2.91 (0.40)

High response

 Cohort

  AMH

11

8639

2.40 (1.84, 2.96)

0.28

< 0.0001

93.02

0.84

0.70 (0.39)

64.75 (< 0.0001)

  AFC

7

4083

2.71 (1.32, 4.09)

0.70

< 0.0001

94.53

1.65

2.74 (1.89)

39.61 (< 0.0001)

  FSH

3

3112

0.89 (-0.25, 2.04)

0.585

0.1262

73.05

0.86

0.74 (1.02)

7.30 (0.02)

Cross Sectional

  AMH

2

401

3.24 (1.57, 4.92)

0.85

0.00

60.99

0.99

0.98 (2.28)

2.56 (0.10)

  FSH

2

235

1.86 (-1.02, 4.75)

1.47

0.20

93.92

2.02

4.08 (6.15)

16.4567 (< 0.0001)

  1. Abbreviations: AFC Antral follicular count, AMH Anti, Mullerian hormone, CI Confidence interval, DOR Diagnostic odds ratio, AUC Area under curve, E2 Estradiol, FSH Follicle stimulating hormone, Ln Logarithm, ORM Ovarian reserve marker, pAUC Partial AUC, SE Standard error, T Tau, T2 Tau squared
  2. *P-value for Ln DOR